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StabilityArc: Decoding Protein Sequence Embeddings into Generalizable Stability Landscapes

Feller, Aaron L. et al.
arXiv (All) · Papers
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biomoleculesi-2j-3machine-learning
Every protein has a unique stability landscape, but the physical consequences of mutation are governed by recurring biochemical constraints. We test whether a shared decoder, trained on measurements from diverse proteins, can interpret these constraints in an unseen target, enabling cross-protein tr
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