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Breaking the deadlock of metallo-β-lactamases: evidence and prospects for Aztreonam/Avibactam
Multidrug-resistant Gram-negative bacteria pose a significant threat to global public health, with resistance mediated by metallo-β-lactamases being particularly prominent. Aztreonam/avibactam (AZA), a novel β-lactam/β-lactamase inhibitor combination, had been approved in China and the European Unio
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