PLOS
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Forward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep
KCNH voltage-gated potassium channels regulate neuronal excitability, yet how their hallmark cyclic nucleotide-binding homology domains (CNBHDs) influence channel gating to regulate behavior remains unclear. Using an unbiased forward genetic screen in Caenorhabditis elegans, we identified a gain-of
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