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Enhancing aqueous solubility and anticancer efficacy of oligochitosan-folate-cisplatin conjugates through oleic acid grafting for targeted nanomedicine development
Oligochitosan is an anticancer water-soluble biomaterial. Conjugating cisplatin (anticancer drug) and folic acid (targeting ligand) with oligochitosan reduces its aqueous solubility, thus requiring excessive drug dose to be biologically active and organic instead of aqueous processing into nanomedic
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