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AZP-3601 SAD and MAD Study in Healthy Subjects and Patients With Hypoparathyroidism

Alexion Pharmaceuticals, Inc. · 2020
ClinicalTrials.gov · Datasets · License: Public Domain · 2020
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This study is investigating the safety, tolerability, pharmacodynamics and pharmacokinetics of AZP-3601 following single and repeated administration in both healthy volunteers and patients with chronic hypoparathyroidism (cHP) The protocol includes 3 parts: * Part A: first-in-human single ascending dose (SAD) study in healthy volunteers * Part B: multiple ascending dose (MAD) study with 2 weeks of treatment in healthy volunteers * Part C: open-label MAD study with a total treatment duration of 3 months in patients with cHP.
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