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Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation

Gillies, Taryn E et al.
eScholarship · Papers
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ERK signaling regulates the expression of target genes, but it is unclear how ERK activity dynamics are interpreted. Here, we investigate this question using simultaneous, live, single-cell imaging of two ERK activity reporters and expression of Fra-1, a target gene controlling epithelial cell ident
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