HAL (France)
open access
The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer’s disease
Misprocessing of amyloid precursor protein (APP) is one of the major causes of Alzheimer’s disease. APP comprises a large extracellular region, a single transmembrane helix and a short cytoplasmic tail containing an NPxY motif (normally referred to as the YENPTY motif). Talins are synaptic scaffold
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