HAL (France)
open access
Hydrophilic interaction chromatography and tandem mass spectrometry for the characterization of methylated oligoribonucleotides
Chemical modifications on oligonucleotides, notably N-6-methyladenosine (m6A) are known for their impact on diverse classes of RNA including micro (mi)RNAs. However, the characterization of these modifications on intact sequences remains challenging. An ion-pair free hydrophilic interaction liquid c
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