HAL (France)
open access
Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action
The NLRP3 inflammasome is an intracellular protein complex that causes inflammation via the release of IL-1β and pyroptosis. NLRP3 activation is associated with many age-related inflammatory diseases, and NLRP3 inhibition is a promising therapeutic strategy. We previously performed a DNA-encoded lib
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