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Extracellular DNA triggers cGAS-STING to promote immune activation
The cGAS-STING pathway is a key signaling mechanism used by the innate immune system to sense cytosolic dsDNA. Upon binding double-stranded DNA (dsDNA), cGAS synthesizes cGAMP, which activates STING and triggers a series of downstream signaling events that promote a type I interferon mediated immune
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