bioRxiv / medRxiv
open access
Genotoxic and metabolic stress drive divergent senescence programs in human microglia
Microglial dysfunction is a hallmark of brain ageing linked to the accumulation of senescent microglial phenotypes that promote chronic neuroinflammation. Both genotoxic and metabolic stress have been implicated in microglial senescence; yet, whether distinct stressors shape senescence programs rema
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