Control of timing and directionality during neurodifferentiation of human induced Pluripotent Stem Cells (iPSC) via miRNA-mediated feedback and feedforward loops.

Development of neural cells follows a unidirectional path, progressing from pluripotent stem cells into a variety of highly differentiated neuronal and glial cell types. Although the intermediate progenitor cells along this path are well characterised, the mechanisms that determine their directional