bioRxiv / medRxiv
open access
CC BY-NC 4.0
AGC kinase homology requires and enables co-targeting for CNS regeneration
Axon regrowth in the central nervous system (CNS) is constrained by robust regulatory networks. Here we show that optimal neurite outgrowth in rodent and human CNS neurons is achieved by co-inhibition of kinases across four closely related clades within the protein kinase A, G, and C (AGC) family. T
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