bioRxiv / medRxiv
open access
CC BY-NC 4.0
Modeling Joint Reference Regions for Omics Biomarkers in UK Biobank Proteomics
Conventional univariate reference intervals (UniRIs) are widely used to identify abnormal biomarker values, but they evaluate each biomarker independently and do not account for coordinated deviations between biomarkers. We developed and evaluated a joint reference region (JRR) framework for plasma
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