bioRxiv / medRxiv
open access
Tripelennamine 1% topical cream versus diphenhydramine 1% topical cream for the relief of histamine-induced itching: A proof-of-concept study in healthy adults.
IntroductionThere is an unmet need for effective topical anti-pruritic medications for acute itch, as there are only a few over-the-counter products that have a direct effect on itch. Tripelennamine is a first-generation antihistamine that would be useful in treating histamine-induced pruritus, howe
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