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Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization
Abstract Gephyrin, the principal scaffolding protein of inhibitory postsynaptic densities, clusters glycine and GABA A receptors via multivalent interactions. It features structured N and C terminal domains connected by an intrinsically disordered linker. Although the structural and functional prope
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