Burnout- and Depression-Like Functional Collapse States — A Within-Person Biomarker Framework for Precision Psychiatry: State-Dependent Multisystem Regulation in High Processing Cost Phenotypes (HPCPh)

Burnout- and depression-like functional collapse is usually interpreted through isolated biological systems, such as hypothalamic–pituitary–adrenal signalling or inflammation. This may miss state-dependent coordination across systems, particularly within individuals whose cognitive and/or sensory pr