bioRxiv / medRxiv
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CC BY-NC-ND 4.0
Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes
INTRODUCTIONAPOE*{varepsilon}4 is the strongest genetic risk factor for Alzheimers disease (AD), yet its effect varies across ancestral populations. As plasma biomarkers increasingly inform AD diagnosis, failure to account for both APOE genotype and genetic ancestry could lead to diagnostic misclass
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