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Semisynthesis of Multiphosphorylated and Acetylated Histone Methyltransferase Dot1L Reveals Synergistic Inhibition of Nucleosomal H3K79 Methylation
Histone methyltransferase Dot1L is the sole non-SET-domain lysine methyltransferase that exclusively catalyzes nucleosomal histone H3 lysine 79 (H3K79) methylation, and its dysregulation is tightly associated with leukemogenesis and other human diseases. While the regulation of Dot1L activity by his
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