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Development of a Stereoselective Route for Kilogram-Scale Synthesis of STING Agonist BMS-986301
Following the discovery of a chiral P(V) reagent to enable diastereoselective synthesis of stereogenic thiophosphoramidates, we have developed a scalable synthesis to deliver kilogram quantities of the STING agonist BMS-986301. The route not only reduced the number of steps compared to the enabling
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