bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
Mathematical Modeling of Late-Stage LC Aggregation and Cardiac Injury Following Establishment of a Pathogenic Plasma-Cell Clone
AL amyloidosis is a rapidly progressive disorder characterized by clonal plasma cell expansion, excessive production of light chains (LCs), and their misfolding into aggregation-prone monomers. These monomers assemble into oligomers and ultimately deposit as amyloid fibrils, particularly within card
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