Post-translational modification integration on the circadian clock protein Period 2 by Casein Kinase 1 and the CREB Binding Protein

Circadian rhythms are generated at the cellular level by a molecular clock oscillator that temporally controls gene expression. These self-sustained biological clocks operate with an intrinsic timing, or period, of ~24-hours but can also respond to external cues, including metabolic signals. Thus, b