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Crystal Structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution

Nathalie Colloc'H et al.
HAL (France) · Papers
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Urate oxidase (uricase) is an enzyme that catalyzes the oxidation of uric acid to allantoin. In humans, the gene encoding this enzyme became inactive during evolution, making uric acid the end product of purine metabolism. Consequently, uric acid may accumulate under certain pathological conditions,
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