HAL (France)
open access
The Murine B Cell Repertoire Is Severely Selected against Endogenous Cellular Prion Protein
Abstract Abs to the prion protein (PrP) can protect against experimental prion infections, but efficient Ab responses are difficult to generate because PrP is expressed on many tissues and induces a strong tolerance. We previously showed that immunization of wild-type mice with PrP peptides and CpG
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