HAL (France)
open access
Restoring brain functions in the Mo-blo mouse model of Menkes disease with copper nanoclusters
Menkes disease, caused by ATP7A mutations, leads to severe copper deficiency and fatal neurodegeneration. Current copper-histidine therapy fails to restore brain function. Copper nanoclusters (CuNCs) were designed for their ultrasmall size to cross physiological barriers and deliver copper directly
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