HAL (France)
open access
A DOE-optimized supercritical fluid chromatography-mass spectrometry workflow complementing liquid chromatography for comprehensive profiling of Trichoderma reesei specialized metabolism
Fungal secretomes are prolific sources of structurally diverse bioactive natural products, including peptaibols, lipopeptides, and polar metabolites. Their chemical complexity makes comprehensive untargeted profiling a persistent analytical challenge, particularly for highly polar compounds that are
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