Scientific Opinion on application (EFSA‐GMO‐UK‐2008‐60) for placing on the market of genetically modified herbicide tolerant maize GA21 for food and feed uses, import, processing and cultivation under Regulation (EC) No 1829/2003 from Syngenta Seeds.

Scientific Opinion on application (EFSA‐GMO‐UK‐2008‐60) for placing on the market of genetically modified herbicide tolerant maize GA21 for food and feed uses, import, processing and cultivation under Regulation (EC) No 1829/2003 from Syngenta Seeds - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice EFSA J . 2011 Dec 16;9(12):2480. doi: 10.2903/j.efsa.2011.2480 Search in PMC Search in PubMed View in NLM Catalog Add to search Scientific Opinion on application (EFSA‐GMO‐UK‐2008‐60) for placing on the market of genetically modified herbicide tolerant maize GA21 for food and feed uses, import, processing and cultivation under Regulation (EC) No 1829/2003 from Syngenta Seeds EFSA Panel on Genetically Modified Organisms (GMO) Article notes Copyright and License information Collection date 2011 Dec. © 2011 European Food Safety Authority PMC Copyright notice PMCID: PMC13093181  PMID: 42016007 Abstract This Scientific Opinion reports on an evaluation of a risk assessment for placing on the market of genetically modified maize GA21 for food and feed uses, import, processing and cultivation. Maize GA21 was developed through particle bombardment and contains a single insertion locus consisting of modified maize epsps ( mepsps ) gene, conferring tolerance to glyphosate‐based herbicides. Bioinformatic analyses and levels of the mEPSPS protein were considered sufficient. The comparative analysis of compositional, agronomic and phenotypic characteristics indicated that maize GA21 is not different from the conventional counterpart and its composition fell within the range observed among non‐GM maize varieties, except for the presence of the mEPSPS protein in maize GA21. The safety assessment of maize GA21 identified no concerns regarding potential toxicity and allergenicity. A feeding study with broiler chickens confirmed that maize GA21 is as nutritious as its conventional counterpart. The EFSA GMO Panel considers that maize GA21 is unlikely to raise additional environmental safety concerns compared to conventional maize, but that its cultivation management could result in environmental harm under certain conditions. The EFSA GMO Panel therefore recommends managing the use of glyphosate on maize GA21 within diversified cropping regimes that have similar or reduced environmental impacts compared with conventional maize cultivation. The EFSA GMO Panel recommends the deployment of case‐specific monitoring to address (1) changes in botanical diversity within fields due to novel herbicide regimes, and (2) resistance evolution to glyphosate in weeds due to novel herbicide regimes. The EFSA GMO Panel agrees with the general surveillance plan of the applicant, but requests that its proposals to strengthen general surveillance are implemented. The EFSA GMO Panel concludes that the information available for maize GA21 addresses the scientific comments raised by Member States and that maize GA21, as described in this application, is as safe as its conventional counterpart and commercial maize varieties with respect to potential adverse effects on human and animal health. If subjected to appropriate management measures, the cultivation management of maize GA21 is unlikely to raise safety concerns for the environment. Keywords: GMO, maize (Zea mays), GA21, herbicide tolerance, mepsps, risk assessment, food and feed safety, environment, environmental safety, food and feed uses, import and processing, cultivation, Regulation (EC) No 1829/2003 EFSA Panel on Genetically Modified Organisms (GMO) ; Scientific Opinion on application (EFSA‐GMO‐UK‐2008‐60) for placing on the market of genetically modified herbicide tolerant maize GA21 for food and feed uses, import, processing and cultivation under Regulation (EC) No 1829/2003 from Syngenta Seeds. EFSA Journal 2011;9(12):2480. [94 pp.] doi: 10.2903/j.efsa.2011.2480. Panel members: Hans Christer Andersson, Salvatore Arpaia, Detlef Bartsch, Josep Casacuberta, Howard Davies, Patrick du Jardin, Gerhard Flachowsky, Lieve Herman, Huw Jones, Sirpa Kärenlampi, Jozsef Kiss, Gijs Kleter, Harry Kuiper, Antoine Messéan, Kaare Magne Nielsen, Joe Perry, Annette Pöting, Jeremy Sweet, Christoph Tebbe, Atte Johannes von Wright, and Jean‐Michel Wal Correspondence: [email protected] Acknowledgement: The Panel wishes to thank the members of the Standing Working Groups on Molecular Characterisation, Food and Feed, and Environment on GMO applications, the external experts Thomas Frenzel and Boet Glandorf, as well as as the EFSA staff member Yann Devos for the preparatory work on this Scientific Opinion, and the EFSA staff members Yann Devos (ENV), Zoltán Divéki (MC) and Antonio Fernandez Dumont (FF) for the support provided to the development of this EFSA scientific output. 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