Withdrawal of Etanercept After Successful Treatment of Juvenile Idiopathic Arthritis

The purpose of this study is to determine whether etanercept can be withdrawn successfully (i.e. no occurrence of flares) in juvenile idiopathic arthritis (JIA) patients in whom disease remission is reached. Goals: 1. to investigate in a randomized controlled trial: * which proportion of JIA patients in remission can successfully discontinue etanercept compared to JIA patients in remission who continue etanercept; * if time in remission on etanercept is an important factor in retaining remission after discontinuation of etanercept. 2. to investigate in alle JIA patients who discontinue etanercept (including the control group): * predicting factors (patient or disease characteristics, including time in remission, and MRP8/MRP14) for successfully discontinuation of etanercept; * the disease course after discontinuation of etanercept (time to flare) and the effect of restarting etanercept after flaring.