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Determining Circadian Metabolic and Behavioural Rhythms in Patients with and Without Type 2 Diabetes

Steno Diabetes Center Copenhagen · 2024
ClinicalTrials.gov · Datasets · License: Public Domain · 2024
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circadian-rhythmcognitionsleeptype-2-diabetes
The goal of the present clinical descriptive study is to characterize and quantify the potential hormonal chronobiological differences between individuals with type 2 diabetes (T2D) and healthy age and weight-matched controls as either circadian aligned or misaligned. The investigators hypothesize that individuals with T2D have a misaligned and different circadian rhythmicity of circadian biomarkers (melatonin and cortisol) than controls, and that this difference in turn is related to 24h hormonal fluctuations, behaviour, and metabolic-, cardiac-, and cognitive parameters. Participants will be asked to: * fill-out a diary on eating and sleeping habits for 30 days * wear an actigraphy and continuous glucose monitor for 10-14 days * stay overnight at the research facility, including continuous blood sampling and polysomnography
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