Europe PMC
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Redefining intranasal brain delivery: from nasal entry to meaningful parenchymal and cellular exposure
Nose-to-brain (N2B) delivery is a promising noninvasive strategy to circumvent the blood‒brain barrier (BBB). However, the clinical translation of N2B platforms remains hindered by a conceptual oversimplification that equates crude central nervous system (CNS) exposure with effective therapeutic del
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