HAL (France)
open access
Comparative Analysis of Toxigenic and Megaplasmid-Free Clostridium tetani Strains Reveals Physiological Transitions Linked to Tetanus Toxin Production
Understanding Clostridium tetani metabolism and physiology is essential for identifying factors controlling toxin synthesis. We compared a toxigenic C. tetani strain with a derivative strain lacking the toxin-encoding megaplasmid carrying tetR and tetX genes involved in toxin regulation and producti
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