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Prothrombinase processivity is conferred by substrate allostery

Fatma Işık Üstok et al.
HAL (France) · Papers
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Abstract The prothrombinase complex, comprised of factor (f) Xa and fVa, converts prothrombin to thrombin through sequential cleavage at two sites in a rapid and processive manner. The molecular basis of prothrombin processing is an enzymatical mystery that to solve requires structural insight into
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