HAL (France)
open access
Optimized alkyne-modified pyridylpiperazine efflux pump inhibitors overcome intrinsic macrolide resistance in multidrug-resistant Klebsiella pneumoniae isolates
Abstract Multidrug-resistant (MDR), ESBL- and carbapenemase-producing Enterobacterales represent a major global health concern requiring novel therapeutic strategies. One promising approach is the development of efflux pump inhibitors (EPIs) targeting the predominant AcrAB-TolC system to sensitize t
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