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Developing a HoxB8 Cell Model of Severe Congenital Neutropenia

Zheng, Sophia et al.
ScholarlyCommons at Penn · Papers · License: CC BY 4.0
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cell-and-developmental-biologyneutropenianeutrophils
Severe congenital neutropenia (SCN) is a rare genetic disorder in which neutrophil precursor cells fail to differentiate past the granulocyte-monocyte progenitor (GMP) stage, resulting in dangerously low neutrophil counts, frequent infections, and impaired wound healing. Mutations in CLPB, a mitocho
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