bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
Divergent genetic mediator signatures of adiposity-related metabolic liabilities and coronary artery disease.
BackgroundObesity and leanness lie at opposite ends of the weight spectrum, yet both carry coronary risk when metabolically dysfunctional. A 2025 Commission redefined obesity around organ function rather than body mass, but whether that distinction reflects a difference in causal architecture, and w
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