bioRxiv / medRxiv
open access
Abdominal Adiposity and Lacunar Stroke: A Mendelian Randomization Mediation Study
BackgroundLacunar stroke accounts for approximately 25% of ischaemic strokes and is linked to metabolic and vascular risk factors. Abdominal adiposity, measured as waist-to-hip ratio adjusted for BMI (WHRadjBMI), is a heritable predictor of cerebrovascular disease independent of overall adiposity, b
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