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Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain

Children's Cancer and Leukaemia Group · 1997
ClinicalTrials.gov · Datasets · License: Public Domain · 1997
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RATIONALE: Drugs used in chemotherapy, such as carboplatin, etoposide, ifosfamide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving more than one drug (combination chemotherapy) with radiation therapy may kill more tumor cells. PURPOSE: This phase III trial is studying combination chemotherapy followed by radiation therapy to see how well it works compared to radiation therapy alone in treating patients with germ cell tumors in the brain.
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