HAL (France)
open access
APOE-Stratified Genome-Wide Association Analyses Provide Insights into the Genetic Etiology of Alzheimers's Disease
Among the more than 90 identified genetic risk loci for late-onset Alzheimer's disease (AD) and related dementias, the apolipoprotein E (APOE) gene ɛ2/ɛ3/ɛ4 polymorphisms remain the longstanding benchmark for genetic disease risk with a consistently large effect across studies1-10. Despite this mass
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