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Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein

Andreas Boland et al.
HAL (France) · Papers
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Argonaute proteins (AGOs) are essential effectors in RNA-mediated gene silencing pathways. They are characterized by a bilobal architecture, in which one lobe contains the N-terminal and PAZ domains and the other contains the MID and PIWI domains. Here, we present the first crystal structure of the
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