Skip to main Communities My dashboard Log in Sign up Bat Literature Project Part of Biodiversity Literature Repository Published 2018 | Version v1 Journal article Restricted TCDD Toxicity Mediated by Epigenetic Mechanisms Authors/Creators Patrizi, Barbara Siciliani De Cumis, Mario Description (Uploaded by Plazi for the Bat Literature Project) Dioxins are highly toxic and persistent halogenated organic pollutants belonging to two families i.e., Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Polychlorinated Dibenzo Furans (PCDFs). They can cause cancer, reproductive and developmental issues, damage to the immune system, and can deeply interfere with the endocrine system. Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism. 2,3,7,8-TCDD is the most toxic among dioxins showing the highest affinity toward the AhR receptor. Beside this classical and well-studied pathway, a number of papers are dealing with the role of epigenetic mechanisms in the response to environmental xenobiotics. In this review, we report on the potential role of epigenetic mechanisms in dioxins-induced cellular response by inspecting recent literature and focusing our attention on epigenetic mechanisms induced by the most toxic 2,3,7,8-TCDD. Files Restricted The record is publicly accessible, but files are restricted. Log in to check if you have access. Additional details Identifiers URL hash://md5/a2c87cf401c4eb6a101da8aa86d7e55d URN urn:lsid:zotero.org:groups:5435545:items:4UMHKHBV DOI 10.3390/ijms19124101 Related works Has version hash://md5/a2c87cf401c4eb6a101da8aa86d7e55d (URL) hash://sha256/0fcfed36ad76be47e5e19d34b9aff6ccaa0f33992d496f8c800fd3830543f7e2 (URL) Is compiled by Software: 10.5281/zenodo.1410543 (DOI) Is derived from zotero://select/groups/5435545/items/4UMHKHBV (URL) https://zotero.org/groups/5435545/items/4UMHKHBV (URL) https://linker.bio/cut:hash://md5/4faceebf0d8b0052910e679abf0cd772!/b300960-303377 (URL) Is part of hash://md5/0157e8ec3f1f8eb877e7b6cd6fde26bc (URL) Biodiversity Kingdom Animalia Phylum Chordata Class Mammalia Order Chiroptera 17 Views 0 Downloads Show more details All versions This version Views Total views 17 17 Downloads Total downloads 0 0 Data volume Total data volume 0 Bytes 0 Bytes More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Keywords and subjects Keywords Biodiversity Mammalia Chiroptera Chordata Animalia bats bat Details DOI DOI Badge DOI 10.5281/zenodo.19670589 Markdown [](https://doi.org/10.5281/zenodo.19670589) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19670589.svg :target: https://doi.org/10.5281/zenodo.19670589 HTML <a href="https://doi.org/10.5281/zenodo.19670589"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19670589.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19670589.svg Target URL https://doi.org/10.5281/zenodo.19670589 Resource type Journal article Publisher Zenodo Published in International Journal of Molecular Sciences, 19(12), 4101, 2018. Citation Export Technical metadata Created April 20, 2026 Modified April 22, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies