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Membrane Proteins at Scale: Automated Copolymer Nanodisc Purification for Structure and Function

Hanisch, P. T. et al.
bioRxiv / medRxiv · Papers · License: CC BY-NC 4.0
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biochemistry
Membrane proteins remain among the most important yet least accessible classes of drug targets. Conventional detergents can remove native lipids, destabilizing proteins and limiting downstream biochemistry and structural biology. Amphiphilic copolymers offer a powerful alternative, directly extracti
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