bioRxiv / medRxiv
open access
CC BY-NC 4.0
The Escherichia coli Radical SAM Enzyme YhcC Replaces MnmC in mnm5s2U tRNA Modification During Anaerobic Growth
tRNA wobble uridines are heavily modified to influence anticodon-codon pairing and tune anticodon stem-loop structure for efficient, accurate translation. Many bacteria and some archaea modify wobble uridines with either a 5-carboxymethylaminomethyl (cmnm5) or 5-methylaminomethyl (mnm5) group, often
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