bioRxiv / medRxiv
open access
Programmable DNA-peptide nanostructures for multivalent regulation of intracellular signalling
The Wnt/{beta}-catenin pathway is constitutively active in most colorectal and other cancers. Tankyrase (TNKS) promotes Wnt signalling by PARylating AXIN, a rate-limiting scaffold subunit of the {beta}-catenin destruction complex, and its inhibition is a validated strategy for pathway downregulation
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