bioRxiv / medRxiv
open access
CC BY 4.0
Lysosomal signaling pathways influence heart rhythm, and regulate atrial function
In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker activity, a distinct Ca2+-ope
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