bioRxiv / medRxiv
open access
CC BY-NC 4.0
IL-27 neutralization promotes pro-inflammatory macrophage polarization and improve response to immune checkpoint blockade
In this study, we investigated the role of interleukin-27 (IL-27) as a regulator of the tumor immune microenvironment (TME) and its impact on the CD39/adenosine metabolic axis. The effects of IL-27 neutralization were evaluated using both in vivo MC38 murine colon adenocarcinoma mode and in vitro hu
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