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Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Attikon Hospital · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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arthroplastychronic-paininterventional-radiologynapain-managementtotal
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
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