Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI

The objective of this clinical trial is to explore the efficacy of menopausal hormone therapy in early menopausal women with CSVD and MCI. The main questions it aims to answer are: * The efficacy of menopausal hormone mainly estrogen therapy for early menopausal women with CSVD and MCI * The role of MHT in delaying the progression of cognitive function, CSVD imaging features, and other clinical symptoms and the potential pathophysiological mechanisms. Participants will be divided randomly into two groups taking MHT drugs and placebo respectively and followed up for 12 months to collect relevant clinical data.