Some Aspects of CD8+ T Cell Exhaustion are Associated with Altered T Cell Mitochondrial Features and ROS content in HIV Infection

BACKGROUND: Reversing or preventing T-cell exhaustion is an important treatment goal in the context of HIV disease; however, the mechanisms that regulate HIV-specific CD8 T-cell exhaustion are incompletely understood. Since mitochondrial mass (MM), mitochondrial membrane potential (MMP), and cellula