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Knockout tales: the versatile roles of histone H3.3 in development and disease

Klein, Rachel H et al.
eScholarship · Papers · License: CC BY
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31-biological-sciences-for-2020
Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes H3f3a and H3f3b have provided important insights into H3.3
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