HAL (France)
open access
Structures of Vibrio cholerae transcription complexes reveal how ToxR and TcpP recruit the RNA polymerase and activate virulence genes
Activation of virulence in Vibrio cholerae , the etiological agent of cholera disease, is mediated by two transmembrane one-component signal-transduction proteins, ToxR and TcpP, which are also transcription factors. Using cryo–electron microscopy, we have solved five structures of the ompU and toxT
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